Chronotoxicological studies on dichlorphos in mice and humans


Tong Jian , Feng Zhiying

DOI:

Received March 11, 1989,Revised , Accepted , Available online

Volume 2,1990,Pages 83-89

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Chronotoxicological studies were performed with dichlorphos (DDVP) and its timing toxic effects on mice and humans. The circadian rhythms were revealed in the blood cholinesterase (ChE) activity in intact mice and normal persons, as well as in mice mortality treated at different daily times. The inverse relationship of the two rhythm suggested that the risk of exposure to DDVP might be much higher at evening hours than in other clocks of the day, and the disappearance of the ChE rhythms in DDVP-treated mice and DDVP-exposed workers implicated a disturbing effect of DDVP on the maintenance and regulation of the rhythmic mechanisms.

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