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This paper deals with the toxic effects of selenium uptakes in the tissues of marine fish. The selenium concentration in skin, liver, muscle and gill of the fish were determined by proton induce X-ray emission (PIXE). The enzyme levels in liver tissues also were measured and evaluated . The results are shown that 50% lethal dose was LD50= 0. 29μg/g and it was found independent on the injected doses. The enzymes in serviving fish showed a gradual and complete recovery during the observation period. A very low Se uptake in muscle was found. The biological half lives of Se concentration in liver and gill were nearly identical, while the skin exhibited a half life 2. 5 times greater.
