Behavior toxicity to Caenorhabditis elegans transferred to the progeny afterexposure to sulfamethoxazole at environmentally relevant concentrations
Zhenyang Yu , Lei Jiang , Daqiang Yin
DOI:
Received August 26, 2010,Revised November 18, 2010, Accepted , Available online
Volume 23,2011,Pages 294-300
- Summary
- References
- Related Articles
Sulfamethoxazole (SMX) is one of the most common detected antibiotics in the environment. In order to study whether SMX can
a ect behavior and growth and whether these e ects could be transferred to the progeny, Caenorhabditis elegans was exposed at
environmentally relevant concentrations for 24, 48, 72 and 96 hr, respectively. After exposure, the exposed parent generation (P0)
was measured for behavior and growth indicators, which were presented as percentage of controls (POC). Then their corresponding
unexposed progeny (F1) was separated and measured for the same indicators. The lowest POC for P0 after 96 hr-exposure at 100
mg/L were 37.8%, 12.7%, 45.8% and 70.1% for body bending frequency (BBF), reversal movement (RM), Omega turns (OT) and
body length (BL), respectively. And F1 su ered defects with the lowest POC as 55.8%, 24.1%, 48.5% and 60.7% for BBF, RM, OT
and BL, respectively. Defects in both P0 and F1 showed a time- and concentration-dependent fashion and behavior indicators showed
better sensitivity than growth indicator. The observed e ects on F1 demonstrated the transferable properties of SMX. Defects of SMX
at environmental concentrations suggested that it is necessary to perform further systematical studies on its ecological risk in actual
conditions.
