Improvement of production of lipopeptide antibiotic iturin A using fish protein
Umme Salma Zohora , Mohammad Shahedur Rahman , Abdul Wahab Khan , Masahiro Okanami , Takashi Ano
DOI:
Received ,Revised , Accepted , Available online March 11, 2014
Volume ,2013,Pages S2-S7
- Summary
- References
- Related Articles
To enhance the production of lipopeptide antibiotic iturin A, nutrient contents of the culture mediums were investigated in both submerged and biofilm fermentations. As a carbon source maltose and as nitrogen source, fish protein was used. In submerged fermentation maltose uptake was found lower (12%) compared to biofilm fermentation (15%) that was associated with higher cellular growth in biofilm. However, requirement of nitrogen (fish protein) concentration was found similar in both submerged and biofilm fermentations. Production of iturin A in submerged fermentation with 12% maltose and 5% fish protein was 4450 mg/L, and in biofilm fermentation it was 5050 mg/L when 15% maltose and 5% fish protein was used.
